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Specialty: Cancer & Oncology
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Total 124207 results found since Jan 2013.
Experimental study in vivo ablation of swine pancreas using high-intensity focused ultrasound
Conclusions: It was feasible and safe to use HIFU for ablation of the pancreas in swine.
Source: Journal of Cancer Research and Therapeutics - March 31, 2019 Category: Cancer & Oncology Authors: Guanghui Huang Xin Ye Xia Yang Aimin Zheng Wenhong Li Jiao Wang Xiaoying Han Zhigang Wei Min Meng Yang Ni Chengkun Qin Xingbo Fei Liulin Xiong Source Type: research
Cellular Therapies for the Treatment of Hematological Malignancies; Swine Are an Ideal Preclinical Model
The absence of clinically relevant large animal tumor models has historically forced experimental cellular therapies for hematological malignancies to translate directly from murine models to clinical trials. However, recent advances highlight swine as an ideal large animal model to demonstrate the safety of murine proof of concept studies prior to their implementation clinically. The availability of the MHC defined MGH miniature swine herd has been key for the development of novel approaches for hematopoietic cell and solid organ transplantation. New spontaneously arising hematological malignancies in these swine, specifi...
Source: Frontiers in Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research
Recombinant hemagglutinin of swine H1N1 influenza virus expression in the insect cells: Formulation in Montanide ISA71 adjuvant and the potency studies
CONCLUSION: To summarize, the results showed that the recombinant protein with the MontanideTM ISA- 71 adjuvant developed a more appropriate level of immunity than Alum adjuvant, so it might be used as a safe and reliable vaccine against H1N1 virus for further research.PMID:35317113 | PMC:PMC8917850 | DOI:10.22038/IJBMS.2021.57053.12716
Source: Cancer Control - March 23, 2022 Category: Cancer & Oncology Authors: Sara Zahmati Morteza Taghizadeh Setareh Haghighat Reza Jalalirad Mehdi Mahdavi Source Type: research
Oxidative stress induced by Se-deficient high-energy diet implicates neutrophil dysfunction via Nrf2 pathway suppression in swine.
Authors: Yang T, Zhao Z, Liu T, Zhang Z, Wang P, Xu S, Len XG, Shan A
Abstract
The mechanism of the interaction between Se deficiency and high energy remains limited. The aim of the current study was to identify whether Se-deficient, high-energy diet can induce oxidative stress, and downregulate the Nrf2 pathway and phagocytic dysfunction of neutrophils. We detected the phagocytic activity, ROS production, protein levels of Nrf2 and Nrf2 downstream target genes, and the mRNA levels of 25 selenoproteins, heat shock proteins, and cytokines in neutrophils. Cytokine ELISA kits were used to measure the serum cytokines. ...
Source: Oncotarget - January 14, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway.
Authors: Chen PG, Guan YJ, Zha GM, Jiao XQ, Zhu HS, Zhang CY, Wang YY, Li HP
Abstract
To explore the role of IRF3/IRF7 during inflammatory responses, we investigated the effects of swine IRF3/IRF7 on TLR4 signaling pathway and inflammatory factors expression in porcine kidney epithelial PK15 cell lines. We successfully constructed eukaryotic vectors PB-IRF3 and PB-IRF7, transfected these vectors into PK15 cells and observed GFP under a fluorescence microscope. In addition, RT-PCR was also used to detect transfection efficiency. We found that IRF3/IRF7 was efficiently overexpressed in PK15 cells. Moreover, we evalua...
Source: Oncotarget - July 15, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
H1N1 (Swine Flu) Treatment Options for People...
What H1N1 (swine flu) treatment options are available for people with cancer? What medications are used for H1N1 (swine flu) treatment, when are they used, and what are the side effects?
Source: About.com Lung Cancer - January 12, 2014 Category: Cancer & Oncology Authors: lungcancer.guide at about.com Tags: health Source Type: news
Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.
Authors: Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S
Abstract
Radiotherapy is commonly used in patients with oral cavity and pharyngeal cancers, usually resulting in irreversible salivary hypofunction. Currently management of radiation damage to salivary glands still remains a great challenge. Recent studies show that activation of mammalian target of rapamycin (mTOR) occurs in salivary gland lesions, making it possible to apply mTOR inhibitor for treatment. Our results indicate inhibition of mTOR by rapamycin significantly alleviated irradiation-induced salivary hypofunctio...
Source: Oncotarget - March 10, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Antioxidant preconditioning attenuates liver ischemia/reperfusion injury after hepatectomy in swine
CONCLUSIONS: This experimental study documents an early protective effect of deferoxamine administration in major hepatectomies against liver ischemia/reperfusion injury.PMID:34268984
Source: Journal of B.U.ON. - July 16, 2021 Category: Cancer & Oncology Authors: Doukakis G Paradellis Georgios Sotirios D Panousopoulos Antonia G Mathioulaki Apostolos E Papalois Tzortzis N Nomikos Stamatios Theocharis Georgios A Gkiokas Nikolaos F Arkadopoulos Source Type: research
